Tesofensine was originally developed for Parkinson's and Alzheimer's but showed remarkable weight loss effects in trials.
Mechanism
Tesofensine inhibits reuptake of serotonin, dopamine, and norepinephrine, reducing appetite and increasing energy expenditure.
Clinical Results
Phase 2 trials showed 10-12% weight loss over 24 weeks at optimal doses.
Research Benefits
- Significant appetite reduction
- Increased metabolic rate
- Improved mood and energy
- Potential cognitive benefits
Dosing
0.25-0.5mg daily (oral capsule form).
Research-grade compounds contain only the active ingredient and are NOT equivalent to FDA-approved pharmaceuticals.